![]() The endoplasmic reticulum is extensively remodeled to form vesicles with two concentric membranes. The painting shows one of the big mysteries of the coronavirus life cycle. at the bottom, the viral nucleocapsid protein is condensing the RNA genome and interacting with the viral membrane (M) protein to package the genome as the virus buds into an endosome.bound to these new membrane structures, several viral enzymes form a replicase complex that is creating new copies of the viral RNA genome.in the middle, viral proteins have reorganized the endoplasmic reticulum membrane to form characteristic networks and double membrane vesicles.at the top, viral RNA is directing the synthesis of viral spike proteins.Several processes are depicted in the painting: ![]() Additional resources for exploring coronavirus are available at PDB-101 and the main RCSB PDB site. The illustration integrates the current state of knowledge, but many aspects of the virus and its life cycle are still actively being studied, so portions of the painting are speculative. The cell’s molecules are shown in blues and greens, and the viral molecules are shown in pinks and purples. It shows a time point when the virus is actively replicating, and new viruses are being created. This illustration shows a cross section through a cell infected with a coronavirus such as SARS-CoV-2. Integrative illustration for coronavirus outreach (2020) PLoS Biol 18: e3000815 doi: 10.1371/journal.pbio.3000815 Goodsell, RCSB Protein Data Bank doi: 10.2210/rcsb_pdb/goodsell-gallery-023 ![]()
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